Amazon pulled NMN from its shelves in March 2023. The FDA had taken the position that a compound already authorised for drug investigation could not be sold as a supplement. That argument was technical, it was never a safety finding, and it ran for two and a half years before the FDA reversed itself on 29 September 2025.
Demand never went anywhere during those two and a half years. Oversight did.
In 2024 a research team published an independent analysis in GeroScience. They bought 18 NMN products off the shelf and ran them through mass spectrometry. Three contained no detectable NMN. Only seven landed within 10 percent of what the label promised. The worst non-zero result measured 13.5 percent of claim, and that one was a liposomal formula, the format brands charge a premium for.
So someone spends four months and $200 on capsules, feels nothing, and concludes their body has stopped responding. They reviewed an empty capsule.
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18 products bought off the shelf and tested
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3 contained no detectable NMN at all
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Only 7 came within 10% of the label claim
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Worst non-zero result: 13.5% of claim
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Source: GeroScience, 2024, no competing interests declared